Interview with Dr. Olia Kisiyev,

Doctor anesthesiologist-reanimatologist,

injection medicine specialist,

Certified trainer

- Oliko, today we are talking about the Spanish brand Clavea product Restore, it is a biostimulator, and let's start this interview from here: what is a biostimulator?

With the abundance of invasive "anti-aging" treatments available in aesthetic medicine today, it’s important to first understand the procedure before diving into specific products. The goal of these treatments is to enhance skin appearance and improve its quality.

A biostimulator or skin booster is a product designed to include a partially stabilized hyaluronic acid molecule, with a specific concentration that mimics the natural structure of the skin. This ensures the product is biocompatible, allowing it to remain in the dermis longer without being broken down quickly by the body's natural hyaluronidase. This results in the formation of hyaluronic acid "depots" within the skin, which provide deep hydration and long-lasting smoothness for several months, and sometimes up to a year.

These treatments also support the metabolic activity of fibroblasts, promoting collagen stimulation. In addition to hyaluronic acid, the formulation may contain auxiliary substances that enhance the product’s viscosity, reduce inflammation and swelling in tissues, and provide antioxidant properties, further improving the overall health and appearance of the skin.

 

 -  How would you describe the product Clavea Restore?

Clavea Restore is an innovative, premium-grade biostimulant developed by the renowned Spanish brand Clavea. This advanced product offers a multifaceted approach to skin rejuvenation and care, targeting deep hydration and overall skin quality improvement. It effectively combats visible signs of both photo-aging and chrono-aging by reducing fine lines and helping to delay the appearance of medium to deep wrinkles.

The formulation contains 2% hyaluronic acid (a combination of 1% low molecular weight and 1% high molecular weight), which ensures long-lasting hydration, enhances skin radiance and smoothness, and promotes collagen stimulation. This reduces the degree of elastosis, while evening out skin tone and texture.

In addition to hyaluronic acid, Clavea Restore is enriched with a complex of minerals—sodium phosphate, sodium chloride, and disodium sulfate—that further enhance the aesthetic, healing, and therapeutic properties of the product, offering a comprehensive solution for healthier, more youthful-looking skin.

- Tell us about Clavea Restore procedure?

The Clavea Restore procedure is recommended for individuals from a relatively young age, depending on specific indications and patient expectations. It can be performed on various areas, including the face, neck, décolletage, shoulders, and wrists. For optimal, long-lasting results, a course of two to three sessions is advised, with each session spaced one month apart.

The product is presented in innovative, specialized packaging featuring three carpules with a single piston, designed for use by one patient only. Each carpule contains the precise volume needed to treat a specific area of the body.

The drug can be administered using various techniques, including linear (retrograde or anterograde), point, marao, or cannula methods, targeting either the mid or deep dermis.

- What can you tell us about the safety and effectiveness of Clavea Restore injections?

Clavea Restore, like other European-manufactured products, undergoes rigorous control of residual protein content and bacterial endotoxins to ensure the highest safety standards. The formulation is designed to be non-cytotoxic and to avoid causing allergic reactions. All components in the product are biocompatible with human tissues, ensuring safe use.

Although no anaphylactic reactions have been reported with Clavea Restore, it does not eliminate the possibility of local or systemic allergic reactions, which may be delayed or immediate and are influenced by various factors. In the rare event of an allergic response, the patient’s condition is managed according to an appropriate medical protocol, taking into account their medical history and any sensitivities to the ingredients in the product.

- How would you distinguish Clavea Restore?

For medical professionals, including myself, the key factors in choosing a product are its high quality, adherence to manufacturing standards, and the completion of proper clinical trials that ensure both safety and effectiveness. Clavea Restore stands out for its ability to deliver the precise results promised to patients. It consistently meets high safety standards, ensuring that both doctors and patients can trust in the outcomes. What truly sets Clavea Restore apart from many other biostimulants on the market is its exceptional safety, quality, and the brilliant results it provides.

- What was the result of the Clavea Restore procedure?

In aesthetic medicine, the results of invasive procedures are typically assessed over time. After performing the Clavea Restore procedure on several patients with varying morphotypes and age ranges, we observed remarkable outcomes. Notably, none of the patients experienced post-injection discomfort, such as stinging, hyperemia, swelling, or any other visible defects. This is a significant advantage for busy professionals, as the procedure requires little to no recovery time, allowing patients to quickly resume their normal routine.

Just hours after the procedure, patients reported smoother skin, a noticeable glow, reduced wrinkles, and a more even tone and texture. As the days progressed, the effects became even more pronounced, delivering impressive, long-lasting results.

Patient 10 minutes after the procedure.

 - Under what circumstances would you recommend Clavea Restore?

As doctors, our primary goal is to provide patients with treatments that deliver the best possible results. When choosing a product, priority is given to one that stands out for its composition, safety, and long-lasting effects. Clavea Restore is precisely that—an exceptional treatment that is effective for both young and older patients, thanks to its carefully selected components.

With a well-planned treatment regimen, Clavea Restore proves to be the ideal solution for rejuvenating the skin’s structure, enhancing its overall health, and giving it a youthful, radiant appearance. It consistently meets the expectations of patients, making it a top choice in aesthetic medicine.