Today we visited one of the well known cliniques in Tbilisi "La Clinique"  
to make this intervie with one of leading doctors there:

Dr. Lika Bareladze – Dermato-venereologist, Trichologist 

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 - Lika, let’s explain to our readers: What Is a New-Generation Tissue Stimulator and How Does It Work?

New-generation tissue stimulators are injectable products used in aesthetic medicine to activate the skin’s natural regenerative processes. Unlike traditional fillers, their primary purpose is not to add volume but to stimulate the skin’s own ability to repair and renew itself.

These products work by activating fibroblasts — the cells responsible for producing collagen and elastin, two essential proteins that maintain the skin’s structure, firmness, and elasticity.

As a result, several visible improvements can be observed:

• Increased synthesis of collagen and elastin
• Improved skin firmness and elasticity
• Reduction in the appearance of wrinkles
• Enhanced skin texture and overall quality

Key Components in Modern Tissue Stimulators

Many of the latest tissue stimulators combine active ingredients that support different aspects of skin regeneration, including:

• Polynucleotides (PN / PDRN) – promote cellular regeneration and tissue repair
• Calcium Hydroxyapatite (CaHA) – stimulates collagen production and improves dermal density
• Poly-L-Lactic Acid (PLLA) – supports long-term collagen formation
• Amino acids and peptides – assist in tissue restoration and metabolic activity

In Simple Terms

A tissue stimulator does not simply “fill” the skin.
Instead, it encourages the skin to restore and rejuvenate itself from within, resulting in gradual, natural-looking improvements.

- Lika, could you introduce our readers to the composition of GEO lifting V+ Silver and explain how its components work?

GEO lifting V+ Silver is a carefully balanced formula that combines two different molecular weights of hyaluronic acid (32 mg/ml) with an active peptide complex. This combination allows the product to work simultaneously on deep hydration, tissue regeneration, and collagen stimulation.

High Molecular Weight Hyaluronic Acid (HMW HA)
High molecular weight hyaluronic acid primarily acts in the upper layers of the skin, where it provides immediate hydration and protection.
Its key functions include:
•    Forming a protective hydration film on the skin surface
•    Reducing transepidermal water loss (TEWL)
•    Improving skin smoothness and hydration
As a result, the skin appears softer, smoother, and better protected from dehydration.

Low Molecular Weight Hyaluronic Acid (LMW HA)
Low molecular weight hyaluronic acid penetrates deeper into the dermis, where it actively participates in skin regeneration.
It helps to:
•    Stimulate fibroblast activity
•    Support the production of collagen and elastin
•    Improve skin density and structural integrity

Peptide Complex
Peptides act as biological signaling molecules that communicate with skin cells and stimulate regenerative processes.
Their main effects include:
•    Activating fibroblasts and enhancing collagen and elastin synthesis
•    Improving skin elasticity, tone, and texture
•    Helping to reduce the depth of wrinkles
•    Supporting tissue repair and improved facial contours
Together, these components create a formula that works on multiple levels of the skin, supporting hydration, structural renewal, and long-term improvement in skin quality.

- Do you agree that, according to current trends in aesthetic medicine, fillers are being replaced by skin regenerative therapies?

In recent years, aesthetic medicine has increasingly focused on approaches that activate the skin’s natural biological processes. Modern treatments aim to stimulate the production of collagen and elastin, improve cellular metabolism, and enhance overall skin quality rather than relying solely on volume correction.
These approaches include:
•    Tissue stimulators
•    Polynucleotides
•    Biostimulators
•    Peptide-based injectable treatments
•    Other regenerative technologies designed to support skin renewal
At the same time, it is important to emphasize that fillers are not disappearing from aesthetic practice. They remain an effective and reliable solution for restoring lost volume and correcting facial contours.
In modern aesthetic practice, a combined approach is often preferred. Regenerative therapies are used to improve skin quality, density, and vitality, while fillers are applied when structural support or volume restoration is required.
In other words, the current trend is not about replacing fillers entirely, but about shifting the focus toward natural-looking results and healthier skin, where regenerative treatments and fillers work in synergy.

- For which patients is Geo Lifting Silver most suitable, and who may not be an ideal candidate?
(Indications and Contraindications)

GEO-LIFTING V™ + V Peptides (Silver) is a tissue stimulator that combines dual molecular weight hyaluronic acid (64 mg / 2 ml) with biomimetic peptides. The formulation is designed primarily to improve skin quality, enhance hydration, and provide a gentle lifting effect.
In clinical practice, I recommend this product to patients who are experiencing early or moderate signs of skin aging, such as mild laxity, changes in facial contours, or a decrease in skin vitality. It is generally not recommended for very young patients, as its purpose is to address age-related changes and prevent their progression.
Ideal Patient (Indications)
Geo Lifting Silver may be suitable for patients with:
•    Reduced skin elasticity and tone
•    Mild to moderate skin laxity
•    Slight irregularities of the facial oval
•    Dehydrated skin with reduced density and uneven texture
•    Early signs of sagging in the lower face (“hamster cheeks”)
The treatment is particularly appropriate for:
•    Patients aged 30+ seeking anti-aging prevention
•    Patients who want to improve skin quality while achieving a subtle lifting effect
Contraindications
As with any injectable procedure, certain conditions should be considered before treatment. The procedure is not recommended in the following cases:
•    Pregnancy or breastfeeding
•    Active skin infections or inflammation in the treatment area (such as acne, dermatitis, or herpes)
•    Active autoimmune diseases
•    Known allergy to hyaluronic acid or other components of the product
•    Tendency to develop keloid scars
In addition, this treatment may not be the best option for patients who require significant volume restoration or structural contour correction, where other injectable approaches may be more appropriate.

- When to Recommend Geo Lifting Silver to Colleagues

I usually advise my fellow cosmetologists to consider Geo Lifting Silver for patients who:
•    Show mild to moderate skin laxity or sagging
•    Need improvement of facial contours, particularly the jawline and oval of the face
•    Exhibit decreased skin density or loss of elasticity
•    Want to enhance skin quality without adding volume, or in combination with fillers
•    Have dehydrated, tired, or dull skin
•    Require biostimulation and activation of collagen synthesis
Additionally, Geo Lifting Silver is an excellent option for preventive anti-aging treatments, particularly for patients aged 30 and above.